Comparison of the pharmacokinetic characteristics of pure salidroside and Kunfukang pills after oral administration
10.12206/j.issn.1006-0111.202006043
- VernacularTitle:红景天苷单体与坤复康片大鼠口服药动学特征的比较
- Author:
Xinzhu LIU
1
;
Renjie XU
2
,
3
;
Cheng FENG
3
;
Xin WEI
1
Author Information
1. Department of Pharmacy, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China.
2. Department of Pharmacy, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China
3. Department of Clinical Pharmacy, Shaoxing Women and Children’s Hospital, Shaoxing 312000, China.
- Keywords:
Kunfukang;
salidroside;
oral administration;
pharmacokinetics
- From:
Journal of Pharmaceutical Practice
2021;39(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetic differences of pure salidroside and Kunfukang pills in rats and explore the pharmacokinetic changes of salidroside as a pure form or in the mixture. Methods The rats were divided into two groups. One group received pure salidroside and the other was administrated with kunfukang pills. Concentrations of salidroside in both groups were determined by LC/MS/MS method. The main pharmacokinetic parameters were calculated. Results AUC0−t of salidroside was (587.11±35.02) in pure salidroside group and (956.35±47.65)ng·h/ml in Kunfukang group. cmax was (85.81±15.66) and (143.86±46.91)ng/ml separately, with significant difference. Conclusion The results indicated that other components in kunfukang pills had influence on the absorption, distribution and elimination of salidroside.
