Preparation and in-vitro drug release of Baizhu Huanglian pellets containing colon-targeting capsules
10.12206/j.issn.1006-0111.202008109
- VernacularTitle:白术黄连微丸结肠靶向胶囊的制备及体外释放研究
- Author:
Xiaomeng TANG
1
;
Jinqian LUO
1
;
Wuqing WANG
2
;
Yongwei GU
3
;
Jiyong LIU
3
,
4
Author Information
1. Department of Pharmacy, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China.
2. Department of Dermatology, Central Hospital of Minhang District, Shanghai 201199, China.
3. Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
4. Department of Pharmacy, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China
- Keywords:
colon-targeting;
extrusion-spheronization technique;
fluid bed coating;
in-vitro drug release
- From:
Journal of Pharmaceutical Practice
2021;39(1):29-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective Colon-targeting capsules based on gastric pellets and enteric pellets were prepared from Baizhu Huanglian prescription. The formulation composition and preparation process were optimized and the in-vitro release characteristics were investigated. Methods Optimum formulation composition and process parameters of Baizhu Huanglian pellets were screened out by single factor experiment and orthogonal design. The pellets core were prepared by extrusion-spheronization technique and coated in the fluid bed using bottom spray coating technique. To investigate the effect of coating level of the isolation layer, the proportion of polymer, the amount of plasticizer and weight gain of enteric coating on the release behavior of the enteric pellets. The pellets release behavior was fitted by model as well. Results The prescription of gastric pellets was drug loading 50%, PVPP 5%, MCC to lactose 1∶2 and wetting agent 40%. The process parameters were extrusion frequency 20 Hz, rounding speed 500 r/min and rounding time 5 min. The prescription of enteric pellets was drug loading 27%, PVPP 5%, MCC to lactose 5∶2, wetting agent 30% and adhesive 20%. The process parameters were extrusion frequency 20 Hz, rounding speed 700 r/min and rounding time 7 min. For enteric coating layer, the coating mixture of EUDRAGIT®L30D-55 to EUDRAGIT® FS30D was 1∶2. The amount of plasticizer was 10%. The increased weight of coating layer was 15%. The release time of enteric pellets in-vitro was up to 24 hours. The release behavior of the pellets conforms to the Higuchi model. Conclusion The colon targeting capsule of Baizhu Huanglian pellets were successfully prepared and showed the characteristics of sustained release and colon targeting.
