Effect of NMN on DSS induced ulcerative colitis in mice
10.12206/j.issn.1006-0111.202006077
- VernacularTitle:烟酰胺单核苷酸对小鼠溃疡性结肠炎的作用
- Author:
Sailong ZHANG
1
;
Qisheng LING
2
;
Zheng YANG
1
;
Chaoyu MIAO
1
Author Information
1. Department of Pharmacology, Naval Medical University, Shanghai 200433, China.
2. School of Pharmacy, Yantai University, Yantai 264005.
- Keywords:
nicotinamide mononucleotide;
ulcerative colitis
- From:
Journal of Pharmaceutical Practice
2021;39(1):13-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Nicotinamide mononucleotide (NMN) on ulcerative colitis induced by dextran sulfate sodium (DSS) in mice. Methods DSS-induced ulcerative colitis mice were used to evaluate the effects of NMN. After NMN administration, the survival time, weight, disease activity index (DAI), colon tissue length and pathological changes of colon tissue slices were observed. Results NMN did not cause significant changes in the survival time, weight, DAI, and intestinal morphology of ulcerative colitis mice. Conclusion NMN has no significant effect on DSS-induced ulcerative colitis mice.
