Small Bowel Pseudomelanosis Associated with Oral Iron Therapy.
10.3346/jkms.2013.28.7.1103
- Author:
Seung Young KIM
1
;
Rok Seon CHOUNG
;
Bo Sung KWON
;
Jong Jin HYUN
;
Sung Woo JUNG
;
Ja Seol KOO
;
Hyung Joon YIM
;
Sang Woo LEE
;
Jai Hyun CHOI
Author Information
1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. crsdr@korea.ac.kr
- Publication Type:Case Reports
- Keywords:
Pseudomelanosis;
Small Bowel;
Iron Therapy
- MeSH:
Adult;
Aged;
Duodenum/pathology;
Endoscopy;
Female;
Humans;
Ileum/pathology;
Intestinal Mucosa/*pathology;
Iron/administration & dosage/*adverse effects;
Jejunum/pathology;
Macrophages/cytology;
Male;
Melanosis/*chemically induced/diagnosis/pathology;
Middle Aged
- From:Journal of Korean Medical Science
2013;28(7):1103-1106
- CountryRepublic of Korea
- Language:English
-
Abstract:
An accumulation of pigment deposits on mucosa, called melanosis or pseudomelanosis, of the small bowel is observed infrequently during endoscopic examination. We describe 6 cases of small bowel pseudomelanosis; the possible etiology of which was chronic iron intake. We observed numerous brown spots in duodenum, jejunum, and terminal ileum during upper and lower endoscopy. Interestingly, all patients have been taking oral iron for several years. Histology showed pigment depositions within macrophages of the lamina propria and a positive Prussian blue stain indicating hemosiderin deposition. Herein, we demonstrate that long term iron therapy may result in pseudomelanosis of small bowel, such as duodenum, jejunum, and ileum.
