Distribution of candidemia in Malaysian tertiary care hospital revealed predominance of Candida parapsilosis
https://doi.org/10.47665/tb.37.4.903
- Author:
Yamin, D.
1
;
Husin, A.
2
,
3
;
Harun, A.
1
,
3
Author Information
1. Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia&
2. Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia&
3. Hospital Universiti Sains Malaysia, Jalan Raja Perempuan Zainab 2, 16150 Kota Bharu, Kelantan, Malaysia
- Publication Type:Journal Article
- From:Tropical Biomedicine
2020;37(No.4):903-910
- CountryMalaysia
- Language:English
-
Abstract:
. Candida parapsilosis is an important pathogen of healthcare-associated
bloodstream infections (BSI) causing high mortality and morbidity in immunocompromised
patients in addition to other Candida species including C. albicans, C. tropicalis, C. glabrata,
and C. krusei. Knowledge on recent local species distribution and trend is essential. An
increase in the proportion of C. parapsilosis candidemia has been recently observed as a
result of many risk factors. The distribution of candidemia has been changing in the last three
decades. To determine the proportion of different Candida species causing candidemia in a
tertiary-care hospital during January 2001 – December 2018, a retrospective study performed
in a 853-bedded tertiary-care hospital in north-eastern Malaysia. All cases of candidemia from
January-2001 to December-2018 were included, and the review was performed based on
patients’ medical records and laboratory database. The frequency of different Candida species
was determined. This study showed that out of 1175 patients with candidemia, C. parapsilosis
was the most common species contributing to 29.2% (343/1175) of candidemia, followed by
C. albicans 20.1% (236/1175), C. tropicalis 18.7% (220/1175), C. glabrata 6.0% (71/1175),
C. guilliermondii 3.7% (43/1175), C. rugosa 1.9% (22/1175), C. famata 1.7% (20/1175),
C. krusei 1.4% (16/1175), C. dubliniensis 0.8% (9/1175), C. lusitaniae 0.7% (8/1175),
C. lipolytica 0.3% (4/1175), C. pelliculosa 0.3% (4/1175), C. haemulonii, C. kefyr, C. utilis and
C. inconspicua (1/1175 each). In addition, 14.9% (175/1175) belonged to Candida spp. which
were not identified to species level. In conclusion, a different scenario for the proportion of
Candida species with C. parapsilosis predominates over C. albicans as a nosocomial pathogen
leading to candidemia has been shown in this study
- Full text:8.2020my1176.pdf
