Effects of Skeletal Muscle on Bone Remodeling through Mechanical Stimulation
10.16156/j.1004-7220.2020.03.18
- VernacularTitle:骨骼肌通过力学刺激对骨重建的影响
- Author:
Mingming XU
1
;
Zhifeng U
1
Author Information
1. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
bone;
muscle;
bone-muscle unit;
endocrine factors;
mechanical stimulation;
bone remodeling
- From:
Journal of Medical Biomechanics
2020;35(3):E385-E390
- CountryChina
- Language:Chinese
-
Abstract:
As the most important tissues of the motor system, skeleton and skeletal muscles are closely related to each other. The concept of bone-muscle units has been proposed for a long time, and they are linked closely by mechanical loading generated by exercise. Skeleton provides mechanical support attachments for skeletal muscle force, and contraction of skeletal muscle drives body movement. During the process of body movement, acting as an intermediate medium between the mechanical load and bone, skeletal muscles regulate metabolic activity of the bone through endocrine factors and mechanical stimulation, which is closely related to continuous bone remodeling and maintains good structure and function of the bone. This review focuses on recent research progress of skeletal muscle affecting bone remodeling by applying mechanical stimulation to the bone, which will provide some new ideas for prevention and treatment of bone metabolism diseases.
