Development of an in vitro Loading Device for Circumferential Stress of Mural Coronary Arteries
10.16156/j.1004-7220.2020.03.08
- VernacularTitle:壁冠状动脉周向应力体外加载装置的研制
- Author:
Hao DING
1
;
Yujia LIU
2
;
Ying ZHANG
2
;
Haoyu LIU
2
;
Mengfei KAN
2
;
Yi ZHUANG
2
;
Geer YANG
3
;
Jie LV
3
Author Information
1. School of Medical Instrument,Shanghai University of Medicine and Health Sciences;School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology
2. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology
3. School of Medical Instrument, Shanghai University of Medicine Health Sciences
- Publication Type:Journal Article
- Keywords:
mural coronary artery;
in vitro loading;
circumferential stress;
atherosclerosis
- From:
Journal of Medical Biomechanics
2020;35(3):E311-E318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To design and develop an in vitro simulation device for circumferential stress of mural coronary artery, so as to achieve the in vitro loading of mural circumferential stress under coronary myocardial bridge oppression with different degrees. MethodsUsing the in vitro simulation device for myocardial bridge coronary artery hemodynamics, the in vitro measurement of mural circumferential stress was achieved. Based on the experimental data, the in vitro loading of mural circumferential stress under coronary myocardial bridge oppression with different degrees was achieved. Results The in vitro measurement experiment showed that the maximum, average and fluctuation of circumferential stress at proximal end of mural coronary artery would increase significantly with the increase in the degree of myocardial bridge oppression. The in vitro loading experiment of mural circumferential stress verified that the loading waveform coincided basically with the experimental waveform from in vitro measurement. Conclusions The device could realize the in vitro loading of mural circumferential stress, which provided an in vitro simulation platform which was as close as possible to the in vivo environment, so as to explore the influence from hemodynamic abnormality of proximal mural coronary artery on the occurrence of atherosclerosis and plaque rupture.