Hemodynamic Characteristics of Pulmonary Arterial Hypertension Related to Congenital Heart Disease
10.16156/j.1004-7220.2020.03.03
- VernacularTitle:先天性心脏病相关性肺动脉高压血流动力学特异性研究
- Author:
Liping WANG
1
;
Jinlong LIU
1
,
2
,
3
;
Mingjie ZHANG
1
;
Juanya SHEN
1
,
2
;
Zhirong ONG
1
,
2
,
4
;
Zhuoming XU
1
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
2. Shanghai Engineering Research Center of Virtual Reality of Structural Heart Disease
3. Pediatric Translational Medicine Institute, Shanghai Jiao Tong University School of Medicine
4. Pediatric Translational Medicine In
- Publication Type:Journal Article
- Keywords:
pulmonary arterial hypertension related to congenital heart disease （PAH-CHD）;
computational fluid dynamics （CFD）;
hemodynamics;
wall shear stress （WSS）;
energy loss
- From:
Journal of Medical Biomechanics
2020;35(3):E276-E283
- CountryChina
- Language:Chinese
-
Abstract:
Objective Hemodynamic disorder of the pulmonary artery (PA) is the main cause of pulmonary arterial hypertension related to congenital heart disease (PAH-CHD). To study the hemodynamic characteristics of PA, so as to understand biomechanical factors in the occurrence and development of PAH-CHD. Methods Clinical and imaging data were collected in five PAH-CHD patients and five matched controls (Non-PAH) to reconstruct subject-specific three-dimensional (3D) PA models. Computational fluid dynamics (CFD) was performed to compare the hemodynamic difference of flow patterns, wall shear stress (WSS) and normalized energy loss (E·) in the two groups. Results Hemodynamics-related parameters showed that the velocity and WSS were higher in the left and right PA branches of PAH-CHD patients, with significantly lower WSS in the main PA. The E· significantly increased in PAH-CHD patients and positively correlated with normalized PA diameter and inflow. Conclusions Compared with Non-PAH subjects, PAH-CHD patients have obviously higher velocity and WSS in PA branches, lower WSS in main PA and greater E·, indicating these hemodynamic parameters are related with the PAH-CHD, which can be used as potential biomechanical factors for the clinical evaluation of PAH-CHD.
