Research Advances in the Effect of Mechanical Regulation of Long-Chain Non-Coding RNAs on Osteogenic Differentiation of Mesenchymal Stem Cells

Wei Cheng; Xianglong Lin; Yang Zhang; Yang Liu; Shuanglong Zhu; Yingjie Liu; Ruixin LI; Yunqiang XU; Xizheng Zhang

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Research Advances in the Effect of Mechanical Regulation of Long-Chain Non-Coding RNAs on Osteogenic Differentiation of Mesenchymal Stem Cells

VernacularTitle:力学调控长链非编码RNA对间充质干细胞成骨分化作用的研究进展
Author: Wei CHENG ^{1
,

2} ; Xianglong LIN ^{2
,

3} ; Yang ZHANG ² ; Yang LIU ^{1
,

2} ; Shuanglong ZHU ¹ ; Yingjie LIU ¹ ; Ruixin LI ⁴ ; Yunqiang XU ¹ ; Xizheng ZHANG ²
Author Information

1. Department of Orthopaedics, General Hospital of Tianjin Medical University
2. Institute of Medical Support Technology, Academy of System Engineering, Academy of Military Science
3. Tianjin Key Laboratory for Advanced Electromechanical System Design and Intelligent Control, Tianjin University of Technology
4. Central Laboratory, Tianjin Stomatological Hospital
Publication Type:Journal Article
Keywords: mechanical regulation; long-chain non-coding RNAs（LncRNAs）; bone marrow stromal cells （BMSCs）; osteogenic differentiation
From: Journal of Medical Biomechanics 2020;35(5):E636-E642
CountryChina
Language:Chinese
Abstract: With the development of the 3rd-generation high-throughput sequencing technology and tissue engineering, recent studies show that many long-chain non-coding RNAs (LncRNAs) have played an important role in osteogenic differentiation of mesenchymal stem cells (MSCs). LncRNAs, which are involved in the regulation of mechanical regulation, further regulate bone-related cell functions and play a regulatory role at multiple levels, including transcription, post-transcriptional and epigenetic. LncRNAs may be involved in the osteogenic differentiation and bone remodeling of MSCs, the regulation of bone-related cell functions as a mechanical response molecule, as well as the pathological process of skeletal diseases.