Research Progress in Effects of Mechanical Factors on Angiogenesis of Vascular Endothelial Cells and the Mechanism
10.16156/j.1004-7220.2020.06.18
- VernacularTitle:力学因素对血管内皮细胞成血管影响及机制的研究进展
- Author:
Jiayi LI
1
;
Bing FANG
2
Author Information
1. School of Medicine, Shanghai Jiao Tong University
2. Department of Orthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
vascular endothelial cells;
mechanical factors;
angiogenesis
- From:
Journal of Medical Biomechanics
2020;35(6):E760-E767
- CountryChina
- Language:Chinese
-
Abstract:
The angiogenic capacity of vascular endothelial cells is influenced by multiple mechanical factors. Mechanical factors guide the rearrangement of cytoskeleton, mediate intracellular signal transduction, affect cell migration, orientation and other behaviors, and then regulate their angiogenic capacity. However, different types of mechanical stimulation have different effects on their angiogenic capacity. This article summarizes and discusses the research work and progress of the influence of five mechanical factors （shear force, stretch stress, low-intensity pulsed ultrasound, microgravity, material properties） on vascular endothelial cell angiogenesis, which provides a basis and ideas for in-depth research of vascular biomechanics.
