Correlation between Biomechanical Changes at the End of Left Ventricular Systole and Pathogenesis of Diastolic Heart Failure
10.16156/j.1004-7220.2020.06.15
- VernacularTitle:左室收缩末期生物力学变化与舒张性心衰发病机制的相关性
- Author:
Yanxia GUI
1
;
Xiaodong SI
2
Author Information
1. Department of Research, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology
2. Department of Pathophysiology, College of Basic Medicine, Inner Mongolia Medical University
- Publication Type:Journal Article
- Keywords:
maximum myocardial stiffness (maxEav);
maximum elastic modulus (Emax);
essential hypertension;
left ventricular diastolic function
- From:
Journal of Medical Biomechanics
2020;35(6):E744-E749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation of the maximum myocardial stiffness (maxEav), maximum modulus of elasticity (Emax) with the E/A ratio of mltral annulus at the end of left ventricular systole for patients with essential hypertension. Methods 298 patients with essential hypertension were selected as research objects. The left ventricular mass index (LVMI) and relative wall thickness (RWT) of the patients were calculated. Based on LVMI and RWT indexes, the patients were divided into left ventricular normal (LVN) group, left ventricular concentric remodeling (LVCR) group, left ventricular eccentric hypertrophy (LVEH) group, left ventricular concentric hypertrophy (LVCH) group, respectively. In addition, 115 healthy subjects were selected into control group. The subjects were diagnosed by echocardiography, so as to analyze the correlation of maxEav, Emax with E/A. Results The maxEav, Emax and E/A in LVCR group, LVEH group and LVCH group were all negatively correlated. The differences of E/A between LVCR group, LVCH group and control group showed statistical significance. Compared with control groups, both the maxEav and Emax in hypertension group decreased, and the difference was statistically significant. Conclusions The maxEav and Emax are more sensitive and easy indexes to judge left ventricular diastolic function. The analysis on maxEav and Emax changes in patients with left ventricular remodeling and diastolic dysfunction in hypertension, as well as the exploration on pathogenesis of diastolic heart failure, can provide the theoretical basis for prevention and treatment of diastolic heart failure in the future.
