The Trans-Scale Conduction Behavior of Fluid Stimulation in Loaded Bone
10.16156/j.1004-7220.2020.02.13
- VernacularTitle:受载骨内液流刺激信号的跨尺度传导行为
- Author:
Weilun YU
1
;
Xiaogang WU
1
;
Chaoxin LI
1
;
Yuqin SUN
1
;
Weiyi CHEN
1
Author Information
1. College of Biomedical Engineering, Taiyuan University of Technology
- Publication Type:Journal Article
- Keywords:
multi-scale;
osteon;
fluid flow;
lacunar-canalicular system;
mechanotransduction
- From:
Journal of Medical Biomechanics
2020;35(2):E208-E215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the conduction behavior of fluid flow induced by physiological loads at different scales of bone. Method sThe multiscale bone models were established by using the COMSOL Multiphysics software, and the fluid behaviors were investigated at macro-, meso- and micro-scale. Results At macro-meso scale，the distribution of pore pressure and fluid velocity of osteon near the periosteum and endoosteum were different from that in other parts. Due to the different structure and material parameters at different layers, the loading and fluid pressure caused different biomechanical responses in the process of transferring from macro-scale to micro-scale. Conclusions The multi-scale layered modeling of bone structure-osteon-lacunae-bone canaliculi was established, which provided the theoretical reference for deeper understanding of fluid stimulation and mechanotransduction.
