Recent advances in G protein coupled receptor 119 agonists
10.16438/j.0513-4870.2020-1303
- VernacularTitle:G蛋白偶联受体119激动剂的研究进展
- Author:
Su-mei SHI
;
Yuan-ying FANG
;
Rong-hua LIU
;
Zun-hua YANG
- Publication Type:Research Article
- Keywords:
G protein coupled receptor 119;
G protein coupled receptor agonist;
type 2 diabetes;
hypoglycemia;
intrinsic activity
- From:
Acta Pharmaceutica Sinica
2020;55(12):2834-2842
- CountryChina
- Language:Chinese
-
Abstract:
G protein-coupled receptor 119 (GPR119) has been a promising target for the treatment of type 2 diabetes. It can not only directly promote insulin secretion, but also indirectly increase insulin secretion by stimulating the release of glucose-dependent GIP/CLP-1 without causing hypoglycemia. The remarkable advantages of small molecule GPR119 agonists make it one of the research hotspots for the development of type 2 diabetes drugs. This article reviews the anti-diabetic small molecules based on the GPR119 target in the past five years.
