Advances in research on mechanisms of diabetic wound healing
10.16438/j.0513-4870.2020-0933
- VernacularTitle:影响糖尿病伤口愈合机制研究进展
- Author:
Nuo-qi WANG
;
Xiu-ying YANG
;
Guan-hua DU
- Publication Type:Research Article
- Keywords:
iabetes;
ound healing;
skin;
oxidative stress;
chronic inflammation
- From:
Acta Pharmaceutica Sinica
2020;55(12):2811-2817
- CountryChina
- Language:Chinese
-
Abstract:
Wound healing is a complex and highly regulated process to maintaining the skin barrier function. Wounds of diabetic patients are hard or even not healing. Non-healing diabetic foot ulcers can lead to lower-extremity amputations. Diabetic wound healing problem is the main complication that leads to high disability rate of diabetes and can threaten the lives in severe cases. The healing of skin wounds requires the synergy of multiple factors to restore the injured skin to its barrier function. The mechanisms that cause it difficult to heal diabetic wounds are complex, including oxidative stress, chronic inflammation, decreased neovascularization, peripheral neuropathy, and imbalance of extracellular matrix accumulation and remodeling. This review classifies mechanisms of diabetic wound healing and provides a reference for its further research.
