Research progress on the abnormal metabolism of macrophages in rheumatoid arthritis pathogenesis
10.16438/j.0513-4870.2020-0708
- VernacularTitle:巨噬细胞异常代谢在类风湿关节炎病理机制中的作用和研究进展
- Author:
Yue-ye WANG
;
Yan CHANG
;
Wei WEI
- Publication Type:Research Article
- Keywords:
macrophage;
rheumatoid arthritis;
metabolism;
rug;
therapy
- From:
Acta Pharmaceutica Sinica
2020;55(12):2827-2833
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages play an important role in the pathogenesis of rheumatoid arthritis (RA). Previously, studies have shown that changes in the metabolism of glucose, choline, amino acids and lipids in macrophages of patients with RA can lead to the accumulation of metabolic intermediates which can act as inflammatory signaling molecules to aggravate the inflammation and cause complications. Therefore, a full understanding of the metabolic process of macrophages in RA patients will lay the foundation for macrophage-targeted therapy of RA. In this review, not only the role of macrophage abnormal metabolism in the pathogenesis of RA but also the research progress on macrophage-targeted drugs in RA treatment will be discussed.
