Recent advances in understanding the roles and molecular mechanisms of cannabidiol in neuropsychiatric disorders
10.16438/j.0513-4870.2020-0672
- VernacularTitle:大麻二酚在神经精神疾病中的作用与分子机制研究进展
- Author:
Jun WU
;
Hai-bo YU
- Publication Type:Research Article
- Keywords:
cannabidiol;
neuronal excitability;
ion channel;
G-protein-coupled receptor;
neuropsychiatric disorder
- From:
Acta Pharmaceutica Sinica
2020;55(12):2800-2810
- CountryChina
- Language:Chinese
-
Abstract:
italic>Cannabis sativa, one of the ancient medicinal plants, has been used to alleviate pain and seizures. However, cannabinoids are often addictive, which limits their clinical use. Cannabidiol (CBD) as a non-psychoactive component of Cannabis sativa, has much weaker adverse effects than Δ9-tetrahydrocannabinol (THC) and therefore has received widespread attention. CBD has been found to ameliorate a variety of neuropsychiatric diseases, but the precise mechanism(s) of action are still unclear. Due to its low affinity for classical cannabinoid receptors current studies are focusing on other targets outside the endocannabinoid system. In the present review we mainly summarize the effects and molecular mechanisms of CBD in neuropsychiatric disorders, including epilepsy, neuropathic pain, anxiety, and depression.
