The role of the intestinal microflora dysbiosis in chronic kidney disease
10.16438/j.0513-4870.2020-0434
- VernacularTitle:肠道菌群-代谢物网络同慢性肾病发生发展的关系及其关联机制研究进展
- Author:
Zhao-jun LI
;
Xiao-guang CHEN
;
Sen ZHANG
- Publication Type:Research Article
- Keywords:
gut microbiota;
chronic kidney disease;
metabolite;
gut-kidney axis
- From:
Acta Pharmaceutica Sinica
2020;55(12):2777-2784
- CountryChina
- Language:Chinese
-
Abstract:
In recent years the interaction between host and gut microbiota has attracted increasing attention. However, intestinal flora dysbiosis may lead to many diseases, and there is increasing evidence that the intestinal microbiota in patients with chronic kidney disease (CKD) is associated with the pathophysiological status of the host. "Gut-kidney axis" provides a better explanation of the two-way communication between intestinal flora and CKD. Impaired kidney function leads to dysbiosis of intestinal flora and an altered intestinal flora can damage the intestinal mucosal barrier and facilitate the entry into the bloodstream of harmful bacteria, which can induce chronic inflammation and thus accelerate renal injury. In addition, the accumulation of nephrotoxic metabolites from an altered intestinal flora can aggravate CKD in the "gut-kidney axis". Among them, p-cresol sulfate, indoxyl sulfate and trimethylamine oxide are the most widely studied metabolites of nephrotoxicity, and their renal toxicity has been widely confirmed in basic research and clinical studies. Current studies show that the intestinal microbiota-metabolite network is closely related to the occurrence and development of chronic kidney disease. Thus, intervention in the intestinal microbiota may provide a new approach to the prevention and treatment of chronic kidney disease.
