Research progress of reactive nitrogen species on cell protection and injury
10.16438/j.0513-4870.2020-0431
- VernacularTitle:活性氮对细胞保护和损伤作用研究进展
- Author:
Su-juan CHEN
1
;
Chen-chen PANG
1
;
Bin LIU
1
;
Chao-shen HUANGFU
2
Author Information
1. School of Nursing and Health, Henan University, Kaifeng 475004, China
2. Institute of Environmental Medicine, Henan University, Kaifeng 475004, China
- Publication Type:Research Article
- Keywords:
reactive nitrogen species;
nitrosative protein modification;
NO3--NO2--NO pathway;
tumor growth;
tumor treatment
- From:
Acta Pharmaceutica Sinica
2020;55(12):2785-2792
- CountryChina
- Language:Chinese
-
Abstract:
Reactive nitrogen species (RNS) affects intracellular redox balance and induces post-translational modification of proteins. Moreover, RNS, as the signal molecule, participates in the transduction of cellular signals under physiological conditions. However, excessive RNS can induce nitrosative stress and then damage cells, and thereby may play a role in the tumor initiation and progression. Thus, we discussed the role of RNS under physiological conditions and the tumor microenvironment, which may provide some novel ideas for the development of new drugs and the treatment of diseases.
