Piperacillin and Its Compound Preparation-induced Anaphylactic Shock ：A Case Report and Literature Analysis
- VernacularTitle:哌拉西林及其复方制剂致过敏性休克的病例报道及文献分析
- Author:
Yaqun HUANG
1
,
2
;
Ruiting WEN
1
;
Zhiying YU
1
;
Chunyan ZHANG
1
;
Xiaolei REN
1
;
Yufei FENG
1
Author Information
1. Dept. of Pharmacy，Peking University People’s Hospital，Beijing 100044，China
2. Dept. of Pharmaceutical Administration and Clinical Pharmacy，School of Pharmaceutical Sciences，Peking University Health Science Center，Beijing 100191，China
- Publication Type:Journal Article
- Keywords:
Piperacillin;
Sulbactam;
Tazobactam;
Anaphylactic shock;
ADR
- From:
China Pharmacy
2021;32(1):82-87
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To i nvestigate the clini cal ch aracteristics of anaphylactic shock induced by piperacillin and its compound preparation ，and to provide reference for prevention and treatment of the severe ADR. METHODS ：A case of anaphylactic shock induced by piperacillin and sulbactam were analyzed in our hospital ，meanwhile ADR literatures about piperacillin alone and its compound preparation-induced anaphylactic shock were collected from Medline ，CNKI，Wanfang database and VIP during the inception to Jul. 2020. Gender and age of patients ，allergic history ，primary disease and treatment ，skin test ， administration route and dosage of piperacillin and its compound preparation ，occurrence time and main manifestations of anaphylactic shock ，treatment measure and prognosis were analyzed ，then prevention and treatment suggestions were put forward. RESULTS：The patient in this case was transferred to the ICU after partial hepatectomy. The use of piperacillin and sulbactam to prevent postoperative infection caused anaphylactic shock. A total of 28 literatures about anaphylactic shock induced by piperacillin and its compound preparations were collected from the database （involving 28 patients）. Among totally 29 patients，there were 12 male and 17 female；the majority of patients were 50-59 years old （6 cases，20.69％）. Three patients had allergic history （food， latex gloves ，etc.），and most of the primary diseases were infectious diseases or the drug used in perioperative period. Skin tests were carried out in 22 patients（75.86％）before medication and the results were negative. The possible allergenic drugs of 27 cases which were administered by intravenous route included piperacillin ，piperacillin sulbactam and piperacillin tazobactam. The dosage was different according to the primary disease and severity. 14 patients（55.56％）developed anaphylactic shock within 5 minutes after drug exposure. The main symptoms were systemic allergic reaction ，mainly involving the circulatory system. Except for two death cases ，the other patients ’symptoms were relieved after treatment. CONCLUSIONS ：Allergic history and skin test results may have limitation in predicting anaphylactic shock induced by piperacillin and its compound preparation. Close monitoring needs to be taken in patients during these medications. Rescue therapy should be prepared in advance and countermeasures need to be carried out promptly in case of anaphylactic shock.
