Heterogeneity of cancer-associated fibroblast and its application in targeted therapy
DOI：10.3872/j.issn.1007-385x.2020.12.002
- VernacularTitle:癌症相关成纤维细胞的异质性及其在靶向治疗中的应用
- Author:
YAN Ting
1
,
2
;
YANG Zhili
1
,
2
Author Information
1. Department of Thyroid, Breast and Hernia Surgery, Sixth People&rsquo
2. s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
- Publication Type:Journal Article
- Keywords:
cancer-associated fibroblasts (CAFs);
tumor microenvironment;
heterogeneity;
targeted therapy
- From:
Chinese Journal of Cancer Biotherapy
2020;27(12):1319-1327
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components in tumor microenvironment, which not only provide physical support for tumor cells, but also play a key role in promoting or delaying tumor occurrence and development. CAFs are a highly abundant and heterogeneous mesenchymal cell line, which contain a large number of cell subsets with different phenotypes and functions. Targeted therapies for CAFs also emerge as demanded. In order to improve the understanding of CAFs in malignant tumors, we elucidate the heterogeneity of CAFs origins, phenotypes and related functions, as well as the research progress of their application in targeted therapy.
- Full text:20201202.pdf
