3.0T MR T2 mapping and T1ρ in distinguishing patients with knee osteoarthritis from healthy individuals: Meta-analysis
10.13929/j.1672-8475.201809005
- Author:
Kun ZHANG
1
Author Information
1. Department of Radiology, First Affiliated Hospital of Hunan University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Cartilage;
Magnetic resonance imaging;
Meta-analysis;
Osteoarthritis
- From:
Chinese Journal of Interventional Imaging and Therapy
2019;16(2):101-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the discriminative validity of 3.0T MR T2 mapping and T1ρ in knee osteoarthritis (KOA) with Meta-analysis. Methods: Case-control studies evaluating articular cartilage in patients with KOA (KOA group) and normal controls (control group) using MR T2 mapping and/or T1ρ before July 31, 2018, in CNKI, VIP, Wanfang, PubMed, EMBASE and Cochrane Library databases were searched. The difference of weight mean difference (WMD) value with their 95%CI between KOA group and control group, as well as between severe and mild KOA patients were analyzed with Stata 14.0 software. Results: A total of 15 articles (420 KOA patients and 450 healthy controls) were involved. T2 value of articular cartilage in KOA group (WMD=4.06, 95%CI [2.73, 5.39]), patients with mild KOA (WMD=2.35, 95%CI [1.15, 3.55]), severe KOA (WMD=8.07, 95%CI [4.03, 12.12]) and unscaled KOA (WMD=1.58, 95%CI [0.51, 2.66]) were higher than that in control group, respectively (all P<0.01), of articular cartilage in severe KOA patient was higher than that in mild KOA patient (WMD=4.66, 95%CI [1.86, 7.46], P<0.01). T1ρ value of articular cartilage in KOA group (WMD=5.41, 95%CI [3.59, 7.22]), patients with mild KOA (WMD=4.25, 95%CI [2.32, 6.18]), severe KOA (WMD=8.44, 95%CI [6.24, 10.64]) and unscaled KOA (WMD=3.51, 95%CI [1.23, 5.79]) were higher than that in control group, respectively (all P<0.01), while of articular cartilage in severe KOA patient was higher than that in mild KOA patient (WMD=6.33, 95%CI [2.02, 10.64], P<0.01). Conclusion: 3.0T MR T2 mapping and T1ρ can be used to distinguish patients with KOA from healthy individuals and identify mild and severe knee osteoarthritis.
