Hepatic arterial infusion of Oxaliplatin combined with Capecitabine in treatment of liver metastases caused by colon cancer
10.13929/j.1672-8475.201809004
- Author:
Hao ZHENG
1
Author Information
1. Anhui Medical University, The Sixth Medical Center of PLA General Hospital
- Publication Type:Journal Article
- Keywords:
Chemotherapy;
Colonic neoplasms;
Interventional therapy;
Liver;
Neoplasm metastasis;
Survival analysis;
Treatment outcome
- From:
Chinese Journal of Interventional Imaging and Therapy
2019;16(3):149-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety of hepatic artery infusion chemotherapy with Oxaliplatin and Capecitabine for treating liver metastases of colon cancer. Methods Data of 50 patients with multiple liver metastases of colon cancer were analyzed retrospectively. A total of 22 patients in group A underwent hepatic arterial infusion chemotherapy with Oxaliplatin and Capecitabine, while the other 28 patients in group B underwent introvenous injection of Oxaliplatin combined with Capecitabine. The efficacy and adverse reaction were analyzed and compared between the two groups. Kaplan-Meier method and Log-rank test were used to assess the progress free survival (PFS) of the two groups. The factors affecting PFS were studied using Cox regression analysis. Results In both two groups, serum carcinoembryonic antigen (CEA) decreased apparently after treatment (both P<0.001), while no statistical difference of CEA was observed between the two groups after treatment (t=1.059, P=0.295). The objective response rate (ORR) of patients in group A and B was 59.09% (13/22) and 35.71% (10/28), and the median PFS was 10.0 and 6.5 months, respectively. There was no significant statistic difference of ORR nor median PFS between the two groups (both P<0.05). The incidence of induced peripheral neurotoxicity in group A was lower than that in group B (χ2=4.266, P=0.039). The pathological type of primary lesion of colon cancer, the number of liver metastatic lesion and the deliever of Oxaliplatin were the factors affecting PFS (all P<0.05). Conclusion Hepatic arterial infusion chemotherapy with Oxaliplatin and Capecitabine is an effective treatment for patients with liver metastases of colon cancer, which can prolong the PFS and reduce the incidence of adverse reaction.
