Application of ultra-high resolution small animal ultrasound imaging system in rat models of abdominal artery implantation
10.13929/j.1672-8475.201809050
- Author:
Zeqin XU
1
Author Information
1. Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Institute of Vascular Surgery of Capital Medical University
- Publication Type:Journal Article
- Keywords:
Aorta, abdominal;
Hemodynamics;
Models, animal;
Rats;
Ultrasonography
- From:
Chinese Journal of Interventional Imaging and Therapy
2019;16(5):304-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the application value of ultra-high resolution small animal ultrasound imaging in rat models of abdominal artery implantation, and to observe the hemodynamic changes of (Poly[ε-caprolactone], PCL)-heparin grafts. Methods: Totally 10 rats were used to establish models of abdominal artery implantation of heparin-conjugated PCL grafts. Ultra-high resolution small animal ultrasound imaging was performed to measure wall thickness, graft luminal diameter and blood flow velocity of heparin-conjugated PCL scaffold in different time points, and then statistical analysis was performed. Results: The wall thicknesses of heparin-conjugated PCL scaffold were significantly different among 1, 2 and 3 months after implantation (F=16.92, P<0.01), also between 1 month and 2 months after implantation (P=0.01), as well as between 1 month and 3 months after implantation (P<0.01). There was no statistic difference of luminal diameter (F=0.08, P=0.99) nor blood flow velocity (F=0.58, P=0.59) of heparin-conjugated PCL scaffold among different time points after implantation. One month after implantation, no aneurysm was found in heparin-conjugated PCL scaffold. However, heparin-conjugate PCL scaffold with aneurysm showed significantly bigger luminal diameter (t=2.94, P=0.03) and lower blood flow velocity (t=4.28, P=0.01) than those without aneurysm 3 months after implantation. Conclusion: Ultra-high resolution small animal ultrasound imaging can be used for accurate measurement of hemodynamic changes of heparin-conjugated PCL scaffolds in rat models of abdominal artery implantation.
