Clinical effectiveness and safety of HIFU in ablation of uterine fibroids with different MR T2WI signals
10.13929/j.1672-8475.201811001
- Author:
Yuting LIU
1
Author Information
1. Department of Obstetrics and Gynecology, The Affiliated Hospital of Southwestern Medical University
- Publication Type:Journal Article
- Keywords:
High-intensity focused ultrasound ablation;
Magnetic resonance imaging;
Signal;
Treatment outcome;
Uterine neoplasms
- From:
Chinese Journal of Interventional Imaging and Therapy
2019;16(6):349-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the ablation effect and safety of HIFU for uterine fibroids with different MR T2WI signals. Methods: Totally 156 patients with 210 uterine fibroids were treated with HIFU ablation. According to preoperative MR T2WI performances, uterine fibroids were divided into low signal group, equal signal group, high signal group and mixed signal group. The preoperative fibroid volume and intraoperative therapeutic dose parameters (sound source power, irradiation time, therapeutic dose and treatment intensity), energy efficiency factor, postoperative ablation rate, fibroid reduction, as well as the incidence of intraoperative and postoperative adverse reactions were compared among 4 groups. Results: There were statistical differences of preoperative fibroid volume (χ2=14.720, P=0.002), irradiation time (F=10.422, P<0.001), therapeutic dose (χ2=30.973, P<0.001), energy efficiency factor (F=3.953, P=0.009) and ablation rate (F=4.313, P=0.006) among 4 groups. The volume of preoperative fibroids in low signal group was significantly lower than that in high signal group (P=0.032) and mixed signal group (P=0.029), respectively. The irradiation time in high signal group was significantly longer than that in low signal group (P<0.001) and mixed signal group (P=0.006), while the treatment dose was significantly greater than that in low signal group (P<0.001), equal signal group (P=0.023) and mixed signal group (P=0.013), respectively. High signal group had higher energy efficiency factors and lower ablation rate than low signal group (P=0.016, 0.003), equal signal group (P=0.012, 0.006) and mixed signal group (P=0.002, 0.003). No serious complication occurred during and after operation. And there were no significant difference of intraoperative and postoperative adverse reactions, such as radiation pain, skin burns, pain in treatment area, vaginal discharge, lower abdominal pain and appendix pain was found among 4 groups (all P>0.05). Conclusion: HIFU treatment is safe and effective for uterine fibroids with different signals of MR T2WI. However, uterine fibroids with high signals on MR T2WI are difficult to ablate, and the postoperative efficacy is relatively poor.
