Endovascular interventional treatment of VX2 hepatocellular carcinoma in rabbits with Nordy-alginate microspheres
10.13929/j.1672-8475.201904048
- Author:
Qiaoli YANG
1
Author Information
1. Department of Radiology, Chongqing Maternal and Child Health Hospital
- Publication Type:Journal Article
- Keywords:
Alginates;
Interventional therapy;
Liver neoplasms;
Vascular endothelial growth factors
- From:
Chinese Journal of Interventional Imaging and Therapy
2019;16(10):625-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of endovascular intervention with Nordy-alginate microspheres (KMG) in treatment of rabbit VX2 hepatocellular carcinoma. Methods: Fifty rabbits with VX2 hepatocellular carcinoma were randomly divided into 5 groups (each n=10). The rabbits were then perfused of different drugs in the target vessels, which in group A was normal saline, in group B was Nordy, in group C was KMG, in group D were 5-fluorouracil+KMG and in Group E were Nordy-KMG. Enhanced CT scanning was performed 1 day before and 2 weeks after operation, and the volume and volume growth rate of tumors were compared among groups. Immunohistochemistry was used to detect the expression of vascular endothelial growth factor (VEGF) in tumor tissue, and the microvessel density (MVD) was counted. Results: There was no significant difference in the volume of tumors among 5 groups 1 day before operation (all P>0.05). Two weeks after operation, the volume and the volume growth rate of tumors in group A and B were higher than those in group C, D and E (both P<0.05). There were significant differences in the positive rate of VEGF and MVD among 5 groups (all P<0.01). The positive rate of VEGF and MVD in group E were lower than those in other groups (all P<0.05). Conclusion: Endovascular interventional therapy with Nordy-KMG is effective for VX2 hepatocellular carcinoma in rabbits.
