Diagnosis of triple negative breast cancer based on gray-scale contrast-enhanced ultrasonography
10.13929/j.1672-8475.201901017
- Author:
Xingyou ZAN
1
Author Information
1. Department of Medical Ultrasound, Wuxi People's Hospital Affiliated to Nanjing Medical University
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Diagnostic imaging;
Triple negative;
Ultrasonography
- From:
Chinese Journal of Interventional Imaging and Therapy
2019;16(11):687-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the gray-scale CEUS features and diagnostic value of triple negative breast cancer (TNBC). Methods: Data of 37 TNBC patients (TNBC group) and 74 non-triple negative breast cancer (NTNBC) patients (NTNBC group) were retrospectively analyzed. The arrival time and peak time of contrast agent in the mass of gray scale CEUS were observed, and the maximum diameter of the lesion was measured. A total of 11 features of gray scale contrast enhancement were recorded, including internal enhancement features, marginal enhancement features, morphology, margin, internal echoes, peripheral radial vessels, internal filling defects and the number of filling defects, enhancement type, internal and peripheral contorted or penetrating vessels, as well as contrast agent retention. Results: The maximum diameter of lesions in TNBC group was significantly larger than that in NTNBC group ([25.26±10.33]mm vs [18.64±6.11]mm, t=4.445, P<0.001]). Moreover, there were statistically significant difference of marginal enhancement characteristics (χ2=6.518, P=0.011), morphology (χ2=15.686, P<0.001), margin (χ2=12.727, P<0.001), peripheral radial vessels (χ2=50.825, P<0.001), internal filling defects (χ2=5.556, P=0.018) and the number of filling defects (χ2=13.096, P<0.001), enhancement type (χ2=13.072, P<0.001) and contrast agent retention (χ2=17.731, P<0.001) between the two groups. No statistically significant difference was found between the two groups in the other characteristics of gray-scale CEUS (all P>0.05). Conclusion: TNBC lesions are larger than NTNBC in general. Certain characteristics displayed in gray-scale CEUS are helpful to differential diagnosis of TNBC and NTNBC.
