Relationships of semiquantitative parameters assessed on 18F-FDG PET/CT and EGFR mutation subtypes in lung adenocarcinoma patients
10.13929/j.issn.1672-8475.2020.02.009
- Author:
Xuhe LIAO
1
Author Information
1. Department of Nuclear Medicine, Peking University First Hospital
- Publication Type:Journal Article
- Keywords:
Adenocarcinoma;
Epidermal growth factor receptor;
Fluorodeoxyglucose F 18;
Lung neoplasms;
Positron-emission tomography
- From:
Chinese Journal of Interventional Imaging and Therapy
2020;17(2):98-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationships of 18F-FDG standardized uptake value (SUV)-derived parameters and mutation subtypes (deletions in exon 19 and a mutation in exon 21) in lung adenocarcinoma patients with mutant epidermal growth factor receptor (EGFR) gene. Methods Data of 64 lung adenocarcinoma patients who underwent 18F-FDG PET/CT scans and EGFR gene mutation test were collected. The relationships of subtype mutation of EGFR gene with four parameters (maximum standardized uptake value [SUVmax], average of standardized uptake value [SUVmean], metabolic tumor volume [MTV] and total lesion glycolysis [TLG]) of primary lesion based on 18F-FDG PET/CT and clinical characteristics were evaluated with univariate and multivariate Logistic regression, respectively. Results The mutant ratio of exon 19 and exon 21 was 23:41. When the parameters were continuous variables, univariate Logistic regression showed exon 21 mutations were found more frequently in the EGFR-positive patients with shorter maximum diameter of primary lesion (OR=0.942, 95%CI [0.890,0.998]) and low level of MTV of primary lesion (pMTV) (OR=0.957, 95%CI [0.923,0.991]). As dichotomous variables, in univariate regression shorter maximum diameter of primary lesion (<26.5 mm: OR=3.759, 95%CI [1.284,11.005]), high level SUVmean (≥4.35: OR=4.267, 95%CI [1.088,16.726]), low level pMTV (<11.2 cm3: OR=7.000, 95%CI [1.798,27.253]) would be significantly related to mutant exon 21. The multivariate Logistic regression displayed that low level of pMTV were found more frequently in exon 21 mutations (OR=8.093, P=0.041). Conclusion: The primary-lesion SUV-derived parameters from 18F-FDG PET/CT of lung adenocarcinoma patients with EGFR-gene mutation associate with the mutant subtypes (exon 19 and 21 mutation) to some extent, but this correlation might be limited.
