Effect of 125I seed implantation combined with chemotherapy in treatment of liver metastasis of advanced colorectal cancer
10.13929/j.issn.1672-8475.2020.06.003
- VernacularTitle: 125I粒子植入联合化学治疗干预晚期结直肠癌肝转移瘤效果
- Author:
Huixian HUANG
1
Author Information
1. Department of Medical Oncology, The Fourth Affiliated Hospital of Guangxi Medical University
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Iodine isotopes;
Liver neoplasms;
Neoplasm metastasis
- From:
Chinese Journal of Interventional Imaging and Therapy
2020;17(6):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical effect and safety of 125I seed implantation combined with chemotherapy in treatment of advanced colorectal cancer with liver metastasis. Methods: Totally 27 cases of advanced colorectal cancer with 60 liver metastasis were enrolled. 125I seed implantation was performed, followed by second-line chemotherapy. The clinical effect, safety and prognosis of the above treatments were observed. Results: Totally 1 995 125I seeds were successfully implanted into 60 liver metastasis([33.41±24.79]seeds in each lesion), and the dose distribution was uniform. Postoperative adverse reactions were mild and recovered after symptomatic treatment. There was no significant difference of liver function before and 1 week after 125I seed implantation. Six patients were treated with oxaliplatin combined regimen and 21 with irinotecan combined regimen 1 week after 125I seed implantation. At the end of 3 and 6 cycles of chemotherapy, the lesion diameter and carcinoembryonic antigen (CEA) level significantly reduced compared with those before implantation (both P< 0.001). The median progression-free survival (PFS) and median overall lifetime (OS) was 8.1 months and 14.6 months, respectively. Conclusion: 125I seed implantation combined with second-line chemotherapy is safe and effective in near future for treating advanced colorectal cancer patients with liver metastasis.
