Safety and efficacy of coaxial puncture 125I particle implantation in treatment of pancreatic head and neck cancer
10.13929/j.issn.1672-8475.2020.09.008
- VernacularTitle: 同轴穿刺植入125I粒子治疗局部晚期胰腺头颈部癌的安全性及有效性
- Author:
Peng DU
1
Author Information
1. Department of Interventional Medicine, The Sixth Medical Center of PLA General Hospital
- Publication Type:Journal Article
- Keywords:
Brachytherapy;
Interstitial irradiation;
Pancreatic neoplasms;
Radiology, interventional
- From:
Chinese Journal of Interventional Imaging and Therapy
2020;17(9):548-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the safety and efficacy of coaxial puncture 125I seed implantation in treatment of locally advanced pancreatic head and neck cancer. Methods: Totally 21 patients with locally advanced pancreatic cancer were retrospectively analyzed. Preoperative planning was performed with treatment planning system (TPS) and fan-shaped distributed system simulated in the same plane. 125I seeds were implanted using coaxial puncture technology, and was operative plan real-timely adjusted during operation. After operation, CT images were imported into TPS for dose verification. Abdominal CT scanning were performed 2, 4 and 6 months after operation to evaluate the treatment efficiency and local control rate, and intraoperative and postoperative complications were counted. Results: The operations were successfully completed in all patients. The effective rate of treatment 2, 4 and 6 months after operation was 38.10% (8/21), 47.62% (10/21) and 52.38% (11/21),and the local control rate was 95.24% (20/21), 80.95% (17/21) and 80.95% (17/21), respectively. Intraoperative complications included 2 cases of local abdominal hemorrhage, 2 cases of subcutaneous soft tissue hematoma and wrong puncture of pancreatic duct in 1 case. Post operation, fever and appetite loss occurred in 10 and 3 cases, respectively. Among 21 patients, grade 0 and grade acute radiation enteritis were observed in 18 and 3 cases, respectively. Conclusion: Coaxial puncture 125I particle implantation technology is safe and effective for treatment of locally advanced pancreatic head and neck cancer.
