Efficacy of percutaneous microwave ablation on low-risk papillary thyroid microcarcinoma and impact on patient's life quality
10.13929/j.issn.1672-8475.2020.10.001
- VernacularTitle: 经皮微波消融治疗低风险甲状腺微小乳头状癌效果及对生活质量的影响
- Author:
Jidong CHEN
1
Author Information
1. Ultrasound Medical Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
- Publication Type:Journal Article
- Keywords:
Microwave ablation;
Quality of life;
Thyroid cancer, papillary;
Ultrasonography, interventional
- From:
Chinese Journal of Interventional Imaging and Therapy
2020;17(10):577-580
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the efficacy of percutaneous microwave ablation on low-risk papillary thyroid microcarcinoma (PTMC) and impact on patient's life quality. Methods: Totally 75 pathologically confirmed patients with single low risk PTMC (T1N0M0) were treated with ultrasound-guided percutaneous microwave ablation and followed up at 1, 3, 6, 12 and 24 months respectively after operation. The therapeutic effect and complications were observed, and score the physical component summary (PCS), mental component summary (MCS) and 36-item short form health survey (SF-36) scores were counted. Results: The operation was successfully completed in all 75 patients. Four patients experienced temporary hoarseness during the ablation process and recovered within 2 h, while 15 patients complained of radiation-induced ear root pain, neck pain and other symptoms which immediately relieved after ablation. Twenty-four months after operation, the effective rate of treatment was 100% (75/75), the lesion disappearance rate was 93.33% (70/75), while no local recurrence occurred. The maximum diameter and volume of lesions increased 1 and 3 months after operation but decreased 6, 12 and 24 months after operation (all P<0.05). There was no significant difference of thyroid stimulating hormone (TSH), free triiodothyronine (FT3) nor free thyroxine (FT4) levels among all time points (all P>0.05). PCS scores at different time points before and after operation showed no statistical significant difference (all P>0.05). MCS scores and SF-36 scores of all time points after operation were higher than those before operation (all P<0.05). Conclusion: Percutaneous ablation is safe and effective for treating low risk PTMC, which can improve the patient's life quality.
