Correlation of Helicobacter pylori Infection With Serum Bilirubin
10.3969/j.issn.1008-7125.2019.01.007
- Author:
Liu HU
1
Author Information
1. Health Management Center, Tongji Medical College, Huazhong University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Bilirubin;
Helicobacter pylori;
Regression Analysis
- From:
Chinese Journal of Gastroenterology
2019;24(1):30-34
- CountryChina
- Language:Chinese
-
Abstract:
Background: Helicobacter pylori (Hp) infection is closely related to a variety of extraintestinal diseases such as coronary heart disease and diabetes, and the mechanism is not yet clear. Low serum bilirubin level is a risk factor of these extraintestinal diseases and may be involved in the pathogenic mechanism of Hp infection. Aims: To investigate the correlation of Hp infection with serum bilirubin. Methods: A total of 10 843 individuals taken routine physical examinations from June 2016 to June 2017 at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology were enrolled. Hp infection was detected. Hp infection rate was compared between groups with different gender, age and BMI. Serum total bilirubin (TBil), direct bilirubin (DBil), indirect bilirubin (IBil) levels between Hp-positive group and Hp-negative group were compared. Correlation of Hp infection with serum bilirubin was analyzed. Results: Hp infection rate was 35.0%. No significant difference in Hp infection rate was found between groups with different gender. However, Hp infection rate was statistically different between groups with different age or BMI (P<0.001). Compared with Hp-negative group, serum TBil, DBil, IBil levels were significantly decreased in Hp-positive group (P<0.001). Multiple linear regression analysis showed that Hp infection was negatively correlated with serum TBil, DBil, IBil levels [regression coefficient was -0.805 (95% CI: -1.256-0.353), -0.134 (95% CI: -0.243-0.026), -0.667 (95% CI: -1.047-0.287), respectively; P<0.001, P=0.015, P=0.001]. Conclusions: Hp infection is negatively correlated with serum TBil, DBil and IBil levels. Hp infection may be involved in the pathogenesis of extraintestinal diseases such as coronary heart disease and diabetes via decreasing serum TBil, DBil and IBil levels.
