Efficacy and Related Factors of Fecal Microbiota Transplantation on Ulcerative Colitis
10.3969/j.issn.1008-7125.2019.03.006
- Author:
Jiajia ZHANG
1
Author Information
1. Shanxi Medical University
- Publication Type:Journal Article
- Keywords:
Colitis, Ulcerative;
Fecal Microbiota Transplantation;
Meta-Analysis;
Therapy
- From:
Chinese Journal of Gastroenterology
2019;24(3):153-159
- CountryChina
- Language:Chinese
-
Abstract:
Background: Fecal microbiota transplantation (FMT) has become a new method for treating some complicated intestinal diseases, and has achieved remarkable effects in the treatment of Clostridium difficile infection (CDI). Aims: To systematically evaluate the efficacy and possible influencing factors of FMT on the treatment of ulcerative colitis (UC). Methods: Clinical trials of FMT for the treatment of UC were retrieved from PubMed, Medline, Embase, CNKI, Chinese Science and Technology Journal Database. Meta-analysis of randomized controlled trials (RCTs) was conducted by RevMan 5.3 software. And influences of different factors on efficacy of FMT were analyzed by meta-analysis of single rate. Results: Eleven clinical trials including 4 RCTs and 7 non-RCTs were included. Meta-analysis for 4 RCTs showed that clinical remission rate and efficacy rate were significantly increased in FMT group than in control group (OR=2.89, 95% CI: 1.70-4.92, P<0.000 01; OR=2.70, 95% CI: 1.31-5.57, P=0.007). Meta-analysis of single rate showed that clinical remission rate was significantly increased in lower digestive tract transplantation group than in upper digestive tract transplantation group (39% vs. 19%, P=0.037), however, no significant difference in clinical remission rate was found among different donor selection groups (P=0.967). Conclusions: The efficacy of FMT for treatment of UC is affirmative, the effect of transplantation through lower digestive tract is better, and the effect is not related with specific donor.
