Expressions and Roles of CLEC4D and CARD9 in Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2019.03.004
- Author:
Xiaobo DU
1
Author Information
1. Department of Gastroenterology, Second Affiliated Hospital of Zhengzhou University, Henan Inflammatory Bowel Disease Center
- Publication Type:Journal Article
- Keywords:
CARD9;
CLEC4D;
Inflammatory Bowel Disease;
Intestinal Immunity;
Lectins, C-Type
- From:
Chinese Journal of Gastroenterology
2019;24(3):144-147
- CountryChina
- Language:Chinese
-
Abstract:
Background: C-type lectin domain family 4 member D (CLEC4D) can induce Th17 cell differentiation and regulate IL-17A expression in systemic fungal infection, and whether CLEC4D plays a role in intestinal immunity has not been reported at home and abroad. Aims: To investigate the expressions and clinical significance of CLEC4D and CARD9 in colon tissue in patients with inflammatory bowel disease (IBD). Methods: A total of 48 IBD patients from October 2016 to June 2018 at the Second Affiliated Hospital of Zhengzhou University were enrolled, including 36 patients with ulcerative colitis (UC) and 12 patients with Crohn's disease (CD). And 30 adjacent normal colon tissues in patients with colon cancer were served as controls. Immunohistochemistry was used to detect the expressions of CLEC4D and CARD9 in colon tissue. And their correlations with clinical characteristics were analyzed. Results: The expressions of CLEC4D and CARD9 in UC group and CD group were significantly higher than those in control group (P<0.05), however, no significant differences in expressions of CLEC4D and CARD9 were found between UC group and CD group (P>0.05). The expressions of CLEC4D and CARD9 in UC group were positively correlated with Mayo score and Baron grade (P<0.05). The expressions of CLEC4D and CARD9 in CD group were positively correlated with CDAI score (P<0.05), but not with SES-CD score (P>0.05). The expressions of CLEC4D and CARD9 in IBD patients were positively correlated with CRP (P<0.05), but not with ESR (P>0.05). Conclusions: The expressions of CLEC4D and CARD9 are elevated in patients with IBD and are closely related to patients' condition. CLEC4D may participate in the intestinal immunity of IBD through the CARD9-related pathway.
