Advances in Research on Epithelial-mesenchymal Transition and Mucin in Tumors
10.3969/j.issn.1008-7125.2019.04.012
- Author:
Yaqin TAN
1
Author Information
1. Gastroenterology Research Center, Army Medical University
- Publication Type:Journal Article
- Keywords:
Epithelial-Mesenchymal Transition;
Mucins;
Neoplasms
- From:
Chinese Journal of Gastroenterology
2019;24(4):243-246
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) is a complex transformation process and plays an important role in the invasion of cancer cells. The morphological transformation in cancer cells are accompanied by various cellular processes such as alterations in cell adhesion, cell matrix degradation, changes in epithelial markers and mesenchymal markers. Mucin (MUC) is widely distributed in epithelial cells of various tissues and organs and plays an important role in EMT. Meanwhile, MUC also can mediate signal transduction and cell adhesion, participate in tumor invasion and metastasis. This article reviewed the advances in research on EMT and MUC in tumors.
