Expressions and Clinical Significance of Insulin-like Growth Factor-1 and its Receptor in Patients With Type 2 Diabetes Mellitus and Gastric Cancer
10.3969/j.issn.1008-7125.2019.04.006
- Author:
Jiazuo ZHU
1
Author Information
1. Department of Oncology, Anhui Province Xuancheng City Central Hospital
- Publication Type:Journal Article
- Keywords:
Diabetes Mellitus;
Insulin-Like Growth Factor;
Receptor, IGF Type 1;
Stomach Neoplasms;
Type 2
- From:
Chinese Journal of Gastroenterology
2019;24(4):215-219
- CountryChina
- Language:Chinese
-
Abstract:
Insulin-like growth factor-1 (IGF-1) is an important mitogenic factor, which has an intense role in promoting proliferation and anti-apoptosis, and is abnormally expressed in many malignant tumors. Aims: To investigate the expressions and clinical significance of IGF-1 and its receptor (IGF-1R) in patients with type 2 diabetes mellitus (T2DM) and gastric cancer (GC). Methods: A total of 338 patients with GC received surgery from Jan. 2010 to Jan. 2013 were enrolled, and were divided into GC group and GC-T2DM group. The expressions of IGF-1 and IGF-1R were detected by immunohistochemistry, and their relationship with clinicopathological parameters were analyzed. The effect of expressions of IGF-1 and IGF-1R on survival of patients was evaluated. Results: Compared with GC group, the positivity rates of IGF-1 (81.3% vs. 42.3%; χ2=31.427, P<0.001), IGF-1R (87.5% vs. 46.7%; χ2=34.794, P<0.001) were significantly increased in GC-T2DM group. The expressions of IGF-1, IGF-1R were related with the degree of tumor differentiation, lymph node metastasis and TNM staging in GC group (P<0.05). The expressions of IGF-1, IGF-1R were related with lymph node metastasis only in GC-T2DM group (P<0.05). Spearman's rank correlation analysis showed that there was a significant positive correlation between expression of IGF-1 and expression of IGF-1R in GC group, GC-T2DM group (P<0.05). No significant difference in survival rate was found between IGF-1 (-) group and IGF-1(+) group, IGF-1R(-) group and IGF-1R(+) group both in GC patients and GC-T2DM patients (P>0.05). Conclusions: Compared with GC patients, the positivity rates of IGF-1 and IGF-1R in GC-T2DM patients are significantly increased, and have certain negative effects on the clinicopathological parameters of the patients, suggesting that the two may promote the development and progression of GC through some mechanism.
