Differences in Distribution of Gastroesophageal Acid Reflux and Bile Reflux During Preprandial and Postprandial Period
10.3969/j.issn.1008-7125.2019.07.010
- Author:
Yuanyuan NIAN
1
Author Information
1. Institute of Gastroenterology, Second Affiliated Hospital of Baotou Medical College
- Publication Type:Journal Article
- Keywords:
Acid Reflux;
Bile Reflux;
Gastroesophageal Reflux;
Postprandial Period;
Preprandial Period
- From:
Chinese Journal of Gastroenterology
2019;24(7):430-432
- CountryChina
- Language:Chinese
-
Abstract:
Background: Besides acid reflux, bile reflux also plays an important role in the mucosal injury and Barrett metaplasia in gastroesophageal reflux disease (GERD). Until now, there are rarely literatures reporting whether bile reflux and acid reflux occur simultaneously, and whether they have the same pathogenic mechanism. Aims: To analyze the differences in distribution of gastroesophageal acid reflux and bile reflux during preprandial and postprandial period. Methods: A retrospective analysis was performed on individuals with typical gastroesophageal reflux symptoms and suspicious of GERD. According to the results of esophageal 24-hour pH-Bilitec 2000 monitoring, the subjects were divided into physiological acid reflux group, pathological acid reflux group and pathological bile reflux group. The preprandial and postprandial profiles of acid and bile reflux were compared. Results: Both physiological and pathological acid reflux were much more frequent during postprandial than preprandial period. In patients with pathological acid reflux, the frequency of postprandial acid reflux was two-fold over the preprandial acid reflux (P<0.05), and the postprandial longest acid reflux time was significantly shorter than preprandial (P<0.05). In patients with pathological bile reflux, the frequency of preprandial bile reflux, the preprandial longest bile reflux time, and time percentage of bile reflux were significantly increased than those of postprandial (P<0.05). Conclusions: Gastroesophageal acid reflux is prone to occur during postprandial period while bile reflux during preprandial period. There may be different mechanisms related with acid reflux and bile reflux.
