Role of Tumor Necrosis Factor-α in Progression of Non-alcoholic Fatty Liver Disease
10.3969/j.issn.1008-7125.2019.10.010
- Author:
Yuecheng GUO
1
Author Information
1. Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Insulin Resistance;
Lipid Metabolism;
Non-Alcoholic Fatty Liver Disease;
Non-Alcoholic Steatohepatitis;
Tumor Necrosis Factor-alpha
- From:Chinese Journal of Gastroenterology
2019;24(10):623-626
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) is a liver manifestation of the metabolic syndrome. The "second strike" theory implies that cytokines play vital roles in the pathogenesis of NAFLD. Tumor necrosis factor-α (TNF-α), an important member of the tumor necrosis factor family, is widely available and has various biological effects. The expression of TNF-α in vivo is tissue-specific and participates in various cellular activities. Low concentration of TNF-α is involved in anti-inflammation, while excessive TNF-α impairs systematic immune balance and contributes to pathological changes along with other inflammatory cytokines. This article reviewed the role of TNF-α in progression of NAFLD.
