Research Progress on Pathogenesis of Hepatic Encephalopathy
10.3969/j.issn.1008-7125.2020.02.011
- VernacularTitle: 肝性脑病发病机制的研究进展
- Author:
Mengyu LI
1
Author Information
1. Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University
- Publication Type:Journal Article
- Keywords:
Ammonia Neurotoxicity;
Astrocytes;
Bile Acid and Salts;
Hepatic Encephalopathy
- From:Chinese Journal of Gastroenterology
2020;25(2):116-120
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic encephalopathy (HE) is a kind of neuropsychiatric syndrome basing on metabolic disorder caused by acute or chronic liver dysfunction or abnormal portosystemic shunt. It is one of the common complications and causes of death in various end-stage liver diseases. The clinical manifestations of patients with HE can vary from personality changes, behavior abnormalities to disturbance of consciousness and coma. The pathogenesis of HE is complex. Theories about ammonia neurotoxicity and alterations in neurotransmitters have been widely accepted. Roles of inflammation, gut microbiota, premature astrocyte senescence, impaired cerebral microcirculation, hemichannel dysfunction, and bile acid also attract much attention. In this review article, the research progress on pathogenesis of HE was briefly summarized.
