Effect of Pentoxifylline on the ICSI Program Undergone in Severe Asthenozoospermia.
- Author:
Jie Ohn SOHN
;
Ji Su SHIN
;
Chang Jin JEONG
;
Yong Seon CHO
;
Ki Boong OUM
;
Dong Hee CHOI
;
Hyun Joo KIM
- Publication Type:Original Article
- MeSH:
Asthenozoospermia*;
Fertilization;
Hospitals, General;
Pentoxifylline*;
Pregnancy Rate;
Sperm Injections, Intracytoplasmic*;
Spermatozoa
- From:Korean Journal of Fertility and Sterility
2002;29(2):97-103
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to evaluate the effect of Pentoxifylline(PF) on the conventional ICSI program undergone in severe asthenozoospermia. METHOD: Total 348 cycles of ICSI programs undertaken at CHA General Hospital from January, 1996 to September, 2000, were divided into two groups - injected with pentoxifylline-treated sperm(PFT, 204 cycles) or non-treated sperm(NPFT, 144 cycles) and the clinical results of PFT group were compared with those of NPFT. RESULTS: PF-treatment on sperm increased their motility of normozoospermia and severe asthenozoospermia. Fertilization rate of PFT group was higher than those of ICSI programs undertaken using sperm of NPFT(70.6% vs. 62.9%, p<0.01). And, ET and clinical pregnancy rates of PFT were slightly higher than those of NPFT(93.1%, 44.2% vs. 90.3%, 36.2%). CONCLUSION: These results showed that treatment of pentoxifylline has a beneficial role on selection of viable sperm in severe asthenozoospermia.
