Value of four scoring systems in predicting liver failure after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma
10.3969/j.issn.1000-8179.2020.12.347
- Author:
Xuekun XIE
1
Author Information
1. Department of Traditional Chinese Medicine, Guangxi Medical University Cancer Hospital
- Publication Type:Journal Article
- Keywords:
Acute-on-chronic liver failure (ACLF);
Hepatocellular carcinoma(HCC);
Liver failure;
Predictive model;
Prognosis;
Transcatheter arterial chemoembolization(TACE)
- From:
Chinese Journal of Clinical Oncology
2020;47(12):614-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the value of the Child-Pugh (CTP), ALBI, MELD, and MELD-Na scores in predicting acute-on-chronic liver failure (ACLF) in patients with hepatocellular carcinoma(HCC) after transcatheter arterial chemoembolization (TACE). Methods: Seven hundred and eleven patients with HCC who received their first TACE treatment at Guangxi Medical University Cancer Hospital between October 2013 and October 2015 were retrospectively analyzed. A Logistic regression analysis and receiver operating characteristic (ROC) curve were used to evaluate the efficacy of the four scoring models in predicting ACLF. Results: The results of the univariate and multivariate analysis showed that the four scoring models could independently predict the occurrence of ACLF after TACE. The ROC curve analysis showed that the area under the ROC curve (AUC) of ALBI was significantly higher than the other three scores (P< 0.001). After different types of ACLF were grouped according to the best truncation (cut-off) values of the four scoring models, it was found that the incidence of ACLF total and ACLF C type in patients with a CTP score >5.5, ALBI >-2.29, MELD >8.08 and MELD-Na >8.08 was higher than those with scores lower than the cut-off values (P<0.001). However, there was no significant difference in the incidence of ACLF A type and ACLF B type between the two groups (P>0.001). Conclusions: The child-Pugh, ALBI, MELD, and MELD-Na scores have certain predictive value for ACLF after TACE treatment, with ALBI having the best predictive value.
