Research progress on the correlation between ferroptosis and breast cancer
10.3969/j.issn.1000-8179.2020.08.369
- VernacularTitle: 铁死亡与乳腺癌治疗相关性的研究进展
- Author:
Xiaoliang XIE
1
Author Information
1. Department of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Ferroptosis;
Reactive oxygen species;
Treatment
- From:
Chinese Journal of Clinical Oncology
2020;47(8):423-426
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis, a recently discovered form of programmed cell death characterized by iron-dependent accumulation of lipid reactive oxygen species, plays an important role in diseases such as breast cancer. Although breast cancer is a common malignant tumor in women, its etiology and pathogenesis remain unclear. However, activation of the ferroptosis pathway is known to affect breast cancer cells by inhibiting their proliferation, mitigating their resistance to chemotherapy drugs, enhancing their sensitivity to radiotherapy, and inhibiting their distant metastases; thus, the ferroptosis pathway is a potential novel target for the treatment of breast cancer. Herein, we summarize the mechanisms of ferroptosis and its potential role in breast cancer treatment.
