Expression of KIF23 in colorectal cancer and its clinical significance
10.3969/j.issn.1000-8179.2020.07.113
- VernacularTitle: KIF23 在结直肠癌中的表达及其临床意义
- Author:
Zhiyu JI
1
Author Information
1. Department of General Surgery, Huaihe Hospital of Henan University
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
KIF23;
Prognosis
- From:
Chinese Journal of Clinical Oncology
2020;47(7):338-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression and clinical significance of KIF23 in colorectal cancer (CRC). Methods: The Cancer Genome Atlas (TCGA) database was used to analyze KIF23 mRNA expression in CRC tissues. A total of 116 patients with CRC tissue specimens and clinicopathological data were collected from Huaihe hospital of Henan University for this study from February 2010 to February 2013, and KIF23 protein was detected by immunohistochemistry. Moreover, the association between KIF23 expression and clinicopathological characteristics was analyzed. Results: TCGA database analysis showed that the KIF23 mRNA expression level is increased in cancer tissue (P<0.05). KIF23 was detected in 61.2% of CRC tissues by immunohistochemistry. Overexpression of KIF23 in CRC tissues was associated with T, N, M, and TNM stages (P<0.05). Kaplan-Meier survival analysis showed that increased KIF23 expression was strongly associated with shorter overall survival and disease-free survival compared with patients with low KIF23 expression (P<0.001). Cox proportional hazard regression confirmed that KIF23 was an independent prognostic factor in patients with CRC. Conclusions: KIF23 is highly expressed in CRC and is a potential molecular marker to predict the occurrence, development, and prognosis of CRC.
