Systematic analysis of cases of lymphoma with autoimmune hemocytopenia reported in the Chinese literature in the past 30 years
10.3969/j.issn.1000-8179.2020.02.032
- VernacularTitle: 近 30 年中国文献报道恶性淋巴瘤合并自身免疫性血细胞减少症的系统性分析
- Author:
Hui LIU
1
Author Information
1. Department of Hematology, People's Hospital of Wuhan University
- Publication Type:Journal Article
- Keywords:
Autoimmune cytopenia;
Autoimmune hemolytic anemia;
Autoimmune neutropenia;
Cold agglutinin syndrome;
Immune thrombocytopenia;
Lymphoma;
Pure red cell aplasia
- From:
Chinese Journal of Clinical Oncology
2020;47(2):89-94
- CountryChina
- Language:Chinese
-
Abstract:
The authors analyzed 140 cases of malignant lymphoma (ML) associated with autoimmune cytopenia (AIC), including autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia (PRCA), and Evans syndrome. The analysis was based on cases reported in the literature as well as the reference lists of papers in this field from 1989 to 2019 by Chinese scholars. The number of cases involving various non-Hodgkin's lymphoma subtypes was small (n=1-28). Nevertheless, interesting and sometimes unexpected differences were noted among different types of ML and AIC. All types of AIC except AIN were seen to coexist with ML, and the increasing order of incidence was as follows: warm antibody-AIHA >ITP >cold antibody-AIHA>PRCA>Evans syndrome. CAS was only seen with B-cell lymphomas, WA-AIHA, and ITP, Evans syndrome was more frequent in B-cell lymphomas and PRCA predominantly occurred with T-cell lymphomas. Anti-lymphoma treatment seemed to be more effective against AIC than conventional therapy with steroids or immunoglobulin. Although based on a literature survey, this compilation of data indicates a complex relation between lymphoma and AIC and warrants more attention and specific studies.
