Comparison of the effects of dexmedetomidine and sufentanil combination and chloral hydrate in pediatric patients during tumor radiotherapy: a randomized controlled trial

VernacularTitle: 右美托咪定滴鼻联合舒芬太尼在儿童肿瘤放射治疗中的应用研究*
Author: Lei MA ¹
Author Information

1. Department of Anesthesiology
Publication Type:Journal Article
From: Chinese Journal of Clinical Oncology 2020;47(2):82-84
CountryChina
Language:Chinese
Abstract: Objective: To compare the effects of dexmedetomidine and sufentanil (DS) combination and chloral hydrate (C) alone in pediatric patients during tumor radiotherapy. Methods: In total, 48 children treated with radiotherapy at Shenzhen People's Hospital from November 2018 to September 2019 were enrolled in this study. Changes in sedation onset, recovery, and radiation treatment time and those in mean arterial blood pressure (MAP), heart rate (HR) and oxygen saturation (SpO2) after sedation, and incidence of adverse reactions were recorded. Results: Overall, 48 patients (24 in Group DS and 23 in Group C) were ultimately included in the analysis after enrollment. Patients in Group DS had shorter recovery time and lower MAP, HR, and incidence of adverse reactions than those in Group C. The onset and treatment time did not significantly differ between the two groups. Conclusions: The use of the combination of dexmedetomidine and sufentanil was safe for pediatric patients during tumor radiotherapy and reduced recovery time. Keywords: dexmedetomidine, nasal drops, sufentanil, children, radiotherapy