Clinical practice of prophylactic nipple- sparing mastectomy and immediate reconstruction in Chinese healthy women with BRCA1/BRCA2 germline mutation
10.3969/j.issn.1000-8179.2020.01.429
- VernacularTitle: BRCA1/2 突变的中国健康女性乳腺预防性切除及期重建的临床实践
- Author:
Dongjie ZHANG
1
Author Information
1. Department of Breast Surgery, Peking University International Hospital
- Publication Type:Journal Article
- Keywords:
BRCA1/2 germline mutation;
Breast reconstruction;
Healthy Chinese women;
Prophylactic mastectomy
- From:
Chinese Journal of Clinical Oncology
2020;47(1):34-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the possibility of prophylactic nipple-sparing mastectomy and immediate reconstruction in healthy Chinese women with BRCA1/BRCA2 germline mutation. Methods: From January 2018 to February 2019, three healthy Chinese women with a BRCA1/ BRCA2 germline pathogenic mutation were treated at the Department of Breast Surgery, Peking University International Hospital (2 cases of BRCA1 mutation and 1 case of BRCA2 mutation); these three women (aged 34-36 years) had a strong family history of breast cancer. Thus, they underwent prophylactic nipple-sparing mastectomy and immediate reconstruction. Results: The operations were successfully completed, and no complications occurred. After a median 18-month follow-up, no breast cancer occurred in the three women; they were satisfied with the reconstructed breast's shape, and their anxiety also significantly reduced. Conclusions: Healthy Chinese women with a BRCA1/ BRCA2 germline mutation and a strong family history of breast cancer can possibly consider prophylactic nipple-sparing mastectomy and immediate reconstruction as options.
