Three-dimensional pseudo-continuous arterial spin labeling assessment of imaging progress in acute ischemic stroke with unilateral middle cerebral artery stenosis
10.13929/j.1003-3289.201805095
- Author:
Xuefeng WANG
1
Author Information
1. Department of Radiology, The Second Affiliated Hospital of Nanchang University
- Publication Type:Journal Article
- Keywords:
Cerebral blood flow;
Collateral circulation;
Magnetic resonance imaging;
Middle cerebral artery;
Spin labeling;
Stroke
- From:
Chinese Journal of Medical Imaging Technology
2019;35(1):41-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the value of three-dimensional pseudo-continuous arterial spin labeling(3D-pcASL)in assessment of imaging progress in acute ischemic stroke with unilateral middle cerebral artery (MCA) stenosis. Methods MRI data of 31 patients of acute ischemic stroke with unilateral MCA stenosis were analyzed retrospectively. According to the whole brain DWI characteristics at the time of admission and within 7 days after admission, the patients were divided into progressive group (n=20) and non-progressive group (n=11). 3D-pcASL with post-labeling delay (PLD) of 1.5 s and 2.5 s were performed. The value of blood flow of collateral circulation (ΔCBF) in bilateral (involved side and healthy side) brain regions,including frontal, parietal, temporal and occipital cortices, anterior watershed, internal watershed, posterior watershed and basal ganglia were measured and compared between 2 groups. ROC curve was used to evaluate the efficacy of each region's ΔCBF at involved side in diagnosis of imaging progress of acute ischemic stroke with unilateral MCA stenosis. Results Progress group had significantly lower ΔCBF value in the posterior watershed of both sides compared with non-progressive group (both P<0.05). The area under ROC curve (AUC) of ΔCBF value in posterior watershed at involved side was 0.750, the sensitivity and specificity was 0.85 and 0.64, while in internal watershed were 0.709, 0.95 and 0.55, respectively. Conclusion 3D-pcASL can estimate the compensatory status of collateral circulation in acute ischemic stroke patients with unilateral MCA stenosis, being helpful to early diagnosis of imaging progress of acute ischemic stroke.
