Resting-state fMRI observation on functional connectivity of primary somatosensory cortex in patients with cervical spondylotic myelopathy
10.13929/j.1003-3289.201804134
- Author:
Chenlei ZHANG
1
Author Information
1. Department of Medical Imaging, The First Affiliated Hospital of Nanchang University
- Publication Type:Journal Article
- Keywords:
Cervical spondylotic myelopathy;
Magnetic resonance imaging;
Somatosensory cortex
- From:
Chinese Journal of Medical Imaging Technology
2019;35(1):36-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore changes of functional connectivity of primary somatosensory cortex (S1) in patients with cervical spondylotic myelopathy (CSM) using resting-state fMRI. Methods Resting-state fMRI was performed in 33 patients with CSM (CSM group) and 23 healthy volunteers (control group). Bilateral S1 were divided into 6 sensory sub-regions (finger, hand, leg, chest, back, face) as the ROI. ROI signals were extracted and analyzed based on the correlation of voxel levels with other brain regions, the functional connection coefficient was obtained, and the functional connection map was constructed. The brain functional connectivity between CSM group and control group were compared with two-sample t test. The correlation between the functional connectivity values of the differential brain regions and the clinical functional scale scores were analyzed. Results Compared with control group, the functional sub-region of the left hand of S1 in CSM group reduced with the left angular gyrus, the left inferior temporal gyrus and the right middle temporal gyrus in the resting state, while the function connection of S1 left leg sensory sub-region and left angular gyrus also reduced. S1 right chest sensory sub-region of CSM group showed significantly decreased functional connectivity with the bilateral angular gyrus, bilateral superior frontal gyrus, left medial superior frontal gyrus, left middle frontal gyrus, left middle temporal gyrus/inferior temporal gyrus and right cerebellum posterior lobe. The functional connection between S1 right leg sensory sub-region and the left angular gyrus reduced (P<0.05, FDR correction). The functional connectivity between S1 left hand sensory sub-region and the left angular gyrus negatively correlated with neck disability index scores (NDI; r=-0.377, P=0.031), while the functional connectivity value of S1 left hand sensory sub-region and left inferior temporal gyrus positively correlated with the upper extremity sensation of the Japanese Orthopaedic Association (JOA) score (r=0.353, P=0.044).The functional connectivity value of S1 right leg sensory sub-region and the left angular gyrus also showed significantly positive correlation with the lower extremity sensation JOA scores (r=0.406, P=0.019). Conclusion The abnormalities in functional connectivity of sensorimotor exist in CSM patients, indicating cortical reorganization in CSM patients.
