Resting-state fMRI observation on functional connectivity of insula in patients with chronic insomnia based on Chinese brain template
10.13929/j.1003-3289.201807211
- Author:
Yanrui SHEN
1
Author Information
1. Department of Radiology, Henan Provincial People's Hospital
- Publication Type:Journal Article
- Keywords:
Functional connectivity;
Magnetic resonance imaging;
Resting-state;
Sleep initiation and maintenance disorders
- From:
Chinese Journal of Medical Imaging Technology
2019;35(1):15-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of insula function integration in patients with chronic insomnia (CI) using functional connectivity (FC) analysis in resting-state fMRI. Methods Totally 22 patients with CI (CI group) and 23 healthy volunteers (control group) underwent resting-state fMRI. The templates based on Chinese brains (Chinese2020) were used for spatial standardization. The bilateral insulae were selected as ROIs, and FC analysis was performed with other voxels to obtain brain regions with abnormal FC between the two groups. Correlation analysis was performed between the brain regions with abnormal FC and clinical parameters. Results Compared with control group, the increased FC brain regions with right insula in CI group included bilateral hippocampus, bilateral parahippocampus, bilateral frontal middle gyrus, right temporal middle gyrus, right precentral gyrus, left temporal inferior gyrus, left fusiform gyrus and left posterior lobe of cerebellum (all P<0.05, number of voxel cluster ≥10, AlphaSim correction), while the increased FC brain regions with left insula in CI group included bilateral hippocampus, bilateral parahippocampus, left fusiform gyrus, left temporal inferior gyrus, left posterior lobe of cerebellum and right anterior lobe of cerebellum (all P<0.05, number of voxel cluster ≥10, AlphaSim correction). Correlation analysis showed the scores of instantaneous memory in CI group were positively correlated with FC of the right insula-right hippocampus, right insula-left hippocampus, left insula-right hippocampus and left insula-left hippocampus (r=0.580, 0.668, 0.454, 0.562, all P<0.05). Conclusion FC is abnormal between the bilateral insulae and multiple brain regions in CI patients, therefore providing neuroimaging evidence for understanding emotional regulation, cognitive impairment, daytime dysfunction and impaired memory mechanisms in CI.
