Correlation of 18F-FDG PET/CT and pulmonary function and inflammatory biomakers in patients with idiopathic interstitial pneumonia
10.13929/j.1003-3289.201807118
- Author:
Haoyuan LI
1
Author Information
1. Imaging Center, Aviation General Hospital
- Publication Type:Journal Article
- Keywords:
Fludeoxyglucose F 18;
Idiopathic interstitial pneumonias;
Positron-emission tomography;
Tomography, X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2019;35(2):209-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship of 18F-FDG PET/CT imaging and pulmonary function and laboratory inflammatory biomarkers in patients with idiopathic interstitial pneumonia (IIP). Methods PET/CT imaging of 20 patients with IIP (IIP group) and 20 patients without pulmonary lesions (control group) were retrospectively analyzed. The maximum standard uptake value (SUVmax) and mean SUV (SUVmean) of the whole lung were measured, and the maximum target-to-back ratio (TBRmax) and mean TBR (TBRmean) were calculated. SUV and TBR were compared between IIP group and control group, and the correlation of TBR and pulmonary function indexes and inflammatory biomarkers in IIP group were evaluated. Results SUVmax, SUVmean, TBRmax and TBRmean in IIP group were significantly higher than those in control group (all P<0.001). In IIP group, negative correlation of TBRmean and forced vital capacity (FVC, r=-0.811, P=0.004), diffusion capacity for carbon monoxide of the lung (DLCO, r=-0.715, P=0.020), forced expiratory volume in 1 second (FEV1, r=-0.698, P=0.025), residual volume (RV, r=-0.844, P=0.002), total lung capacity (TLC, r=-0.693, P=0.026) and RV/TLC (r=-0.711, P=0.021) were observed, as well as positive correlation between TBRmean and FEV1/FVC (r=0.888, P=0.001). There were negative correlations of TBRmax and FVC (r=-0.667, P=0.035) and RV (r=-0.643, P=0.045), while no obvious correlation was found between TBRmax and DLCO, FEV1, FEV1/FVC, TLC, RV/TLC (all P>0.05), nor between TBR and erythrocyte sedimentation rate and C-reaction protein (both P>0.05). Conclusion: The radioactive uptake increases in IIP patients, which has certain correlation with pulmonary function.
