Ultrasonographic features of calcified and non-calcified ductal carcinoma in situ of breast and their expression of estrogen receptor and human epidermal growth factor receptor-2
10.13929/j.1003-3289.201808030
- Author:
Caixia PANG
1
Author Information
1. Department of Ultrasound,s,Ningbo Women & Children's Hospital
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Calcification;
Carcinoma, intraductal, noninfiltrating;
Human epidermal growth factor receptor-2;
Receptors, estrogen;
Ultrasonography
- From:
Chinese Journal of Medical Imaging Technology
2019;35(3):367-370
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the ultrasonographic features of calcified and non-calcified ductal carcinoma in situ (DCIS) of breast, and to explore the difference of the expression of estrogen receptor (ER) and human epidermal growth factor receptor-2 (Her-2). Methods A total of 148 patients with pathologically confirmed DCIS were retrospectively analyzed and divided into calcified DCIS group (n=66) and non-calcified DCIS group (n=82) according to the presence of microcalcification in ultrasonography. The differences of the ultrasonographic features, ER and Her-2 positive expression were analyzed. Results The signs of mass, ductal ectasia and elastographic scores showed statistically significant differences between the 2 groups (all P<0.05), while the signs of spiculation, posterior echo attenuation, resistance index and aspect ratio showed no statistically significant difference (all P>0.05). ER positive rate was 42.42% (28/66) in calcified DCIS group and 69.51% (57/82) in non-calcified DCIS group. The difference of ER positive rate between the two groups was statistically significant (P<0.01). Her-2 positive in calcified DCIS group was 30.30% (20/66), while in the non-calcified DCIS group was 14.63% (12/82; P=0.02). Conclusion The ultrasonographic features are different between calcified breast DCIS and non-calcified DCIS. Positive ER is more common in non-calcified DCIS, while high Her-2 expression is more common in calcified DCIS, indicating that calcified DCIS may have rather aggressive histological features.
